publications
2026
- Chromosome-level Genome Assembly and Annotation of the Degu (Octodon degus)bioRxiv, 2026In one sentence
Delivers a chromosome-level genome assembly and annotation of the degu, a natural animal model for aging and Alzheimer’s disease.
- An Integrative Single-Cell Epigenomic Atlas Annotates the Regulatory Genome of the Adult Mouse BrainbioRxiv, 2026In one sentence
Profiles four histone modifications and the transcriptome in 2.5 million mouse brain nuclei to assign chromatin states across 81 percent of the genome.
- A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal GangliabioRxiv, 2026In one sentence
Maps DNA methylation and 3D genome conformation in over 260,000 nuclei across the human basal ganglia, showing how chromatin structure distinguish spiny projection neuron subtypes.
- Single-molecule spatial genomics reveals the multi-scale organization and plasticity of extrachromosomal DNA in glioblastomabioRxiv, 2026In one sentence
Uses single-molecule spatial genomics to show how EGFR ecDNA in glioblastoma is organized, transcribed and shaped by the tumor microenvironment.
- NuRD-enabled CTCF-TET crosstalk orchestrates epigenome reprogramming and genome architectureMolecular Cell, 2026In one sentence
Shows that the NuRD complex is required for CTCF binding and helps CTCF recruit TET enzymes to keep nearby DNA unmethylated, shaping genome architecture.
- Single-cell analysis of the epigenome and 3D chromatin architecture in the human retinaScience Advances, 2026In one sentence
Profiles gene expression, chromatin accessibility, DNA methylation and 3D genome in the human retina to annotate regulatory elements across 23 cell types.
2025
- Context-Dependent and Gene-Specific Role of Chromatin Architecture Mediated by Histone Modifiers and Loop-extrusion MachinerybioRxiv, 2025In one sentence
Shows that cohesin and CTCF regulate genes in a context- and gene-specific way, and uses a CRISPR screen to find protein complex members that modulate their insulation.
2023
- A comparative atlas of single-cell chromatin accessibility in the human brainScience, 2023In one sentence
Maps open chromatin in 1.1 million cells across 42 human brain regions, defining 107 cell types and linking their regulatory elements to neuropsychiatric disease risk.