publications

2026

  1. Single-cell multiomics and chromatin structure reveal gene-regulatory dynamics in heart failure
    Yang Xie, Luca Tucciarone, Elie N Farah, and 8 more authors
    Science, 2026
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  2. Chromosome-level Genome Assembly and Annotation of the Degu (Octodon degus)
    Jeffrey H Chiu, Nathan R Zemke, B Maximiliano Garduño, and 8 more authors
    bioRxiv, 2026
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  3. Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Programs in the Human Brain
    Yang Xie, Lei Chang, Guojie Zhong, and 8 more authors
    bioRxiv, 2026
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  4. An Integrated Single-Cell and Epigenomic Resource for Comparative Analysis of the Basal Ganglia
    Wenjin Zhang, Wubin Ding , Kai Li, and 8 more authors
    bioRxiv, 2026
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  5. An Integrative Single-Cell Epigenomic Atlas Annotates the Regulatory Genome of the Adult Mouse Brain
    Zhaoning Wang, Songpeng Zu, Ethan J Armand, and 8 more authors
    bioRxiv, 2026
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  6. Single-cell Multiome Analysis of Chromatin State and Transcriptome in the Human Basal Ganglia
    Lei Chang , Kai Li, Yang Xie, and 8 more authors
    bioRxiv, 2026
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  7. A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia
    Wubin Ding, Amit Klein, Cindy Tatiana Báez-Becerra, and 8 more authors
    bioRxiv, 2026
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  8. Single-molecule spatial genomics reveals the multi-scale organization and plasticity of extrachromosomal DNA in glioblastoma
    Brett Taylor, Weixiu Dong, Tula Keal, and 8 more authors
    bioRxiv, 2026
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  9. NuRD-enabled CTCF-TET crosstalk orchestrates epigenome reprogramming and genome architecture
    Wenju Sun, Nan Wu, Minhui Xia, and 8 more authors
    Molecular Cell, 2026
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  10. Single-cell analysis of the epigenome and 3D chromatin architecture in the human retina
    Ying Yuan, Pooja Biswas, Nathan R Zemke, and 8 more authors
    Science Advances, 2026
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  11. A Community Standard Multispecies Cell Atlas of the Basal Ganglia
    The BRAIN Initiative Cell Atlas Network
    bioRxiv, 2026
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2025

  1. Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues
    Lei Chang, Yang Xie, Brett Taylor, and 8 more authors
    Nature Biotechnology, 2025
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  2. Context-Dependent and Gene-Specific Role of Chromatin Architecture Mediated by Histone Modifiers and Loop-extrusion Machinery
    Melodi Tastemel, Adam Jussila, Bharath Saravanan, and 6 more authors
    bioRxiv, 2025
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  3. Single cell multiomics reveals drivers of metabolic dysfunction-associated steatohepatitis
    Weston Elison, Lei Chang, Yang Xie, and 8 more authors
    medRxiv, 2025
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2023

  1. A comparative atlas of single-cell chromatin accessibility in the human brain
    Yang Eric Li, Sebastian Preissl, Michael Miller, and 8 more authors
    Science, 2023
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  2. Droplet-based single-cell joint profiling of histone modifications and transcriptomes
    Yang Xie, Chenxu Zhu, Zhaoning Wang, and 4 more authors
    Nature Structural & Molecular Biology, 2023
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  3. Single-cell analysis of chromatin accessibility in the adult mouse brain
    Songpeng Zu, Yang Eric Li , Kangli Wang, and 8 more authors
    Nature, 2023
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  4. Conserved and divergent gene regulatory programs of the mammalian neocortex
    Nathan R Zemke, Ethan J Armand , Wenliang Wang, and 8 more authors
    Nature, 2023
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