research
Our body is a complex system. Each cell in our body can have different roles and developmental trajetories, even though they usually have the same genes. The diversity is mainly driven by the way genes are turned on and off in specific places and times. This precious regulation process is controlled by different elements in our genome, through various chemical modifications and conformation changes in DNA or associated proteins, all of which make up what we call the epigenome.
Being able to probe the dynamics of the epigenome in individual cells can provide insights into a cell’s history, and in some cases, predict its future. This knowledge is crucial for mapping the complex landscapes of biological processes, and designing more precise and effective therapies for diseases.
My current research focuses on developing a toolkit to measure various types of epigenetic changes at the single-cell level. This will enable us to capture a comprehensive picture of how these changes influence cell function and disease progression.
method · 2025
Droplet Hi-C
Single-cell method for chromatin structure profiling
Introduces Droplet Hi-C, which profiles 3D chromatin architecture in single cells at scale and detects structural variants and ecDNA in cancer cells.
method · 2023
Droplet Paired-Tag
Single-cell method for joint analysis of histone marks and transcriptome
Introduces Droplet Paired-Tag, a fast and robust droplet-based method that profiles histone modifications and gene expression in the same single cells.
application · 2026
Human brain multimodal atlas
A multimodal histone modification and transcriptome atlas for adult human brain
Jointly profiles transcriptomes with active and repressive histone marks in over 750,000 nuclei across 18 human brain regions and tells how developmental information is stored in repressive chromatin.
application · 2026
Human heart failure multimodal atlas
Dissect regulatory networks underlying heart failures
Maps transcriptomes, chromatin states and 3D genome structure in failing and nonfailing human hearts to reveal cell-type-specific regulatory changes in heart failure.
